InPes
Biomaterial storage & transportation company
TECHNOLOGY
FOR VIABLE PRESERVATION
FOR VIABLE PRESERVATION
InPes
Biomaterial storage & transportation company
TECHNOLOGY
FOR VIABLE PRESERVATION
FOR VIABLE PRESERVATION
PROBLEM
>6000
People die every year because of not getting a heart for transplantation
>3,5 years
Waiting time
100 000
People on the heart transplant waiting list
SOLUTION
InPres preservation technology – higher quality/long term (12 hours)
1.0
we provide longer organ's storage
3.0
More organs
for transplantation
for transplantation
2.0
Longer distance/area for organs transportation
SOLUTION
InPres preservation technology – higher quality/long term (12 hours)
1.0
we provide longer organ's storage
3.0
More organs
for transplantation
for transplantation
2.0
Longer distance/area for organs transportation
BUSINESS MODEL
BIOMATERIAL TYPE POSSIBLE TO PRESERVE:
Biomaterial
transportation
company
transportation
company
Sales of equipment
(fridges) leveraging
InPres technology
(fridges) leveraging
InPres technology
Sell technology/
IP license
IP license
BIOMATERIAL TYPE POSSIBLE TO PRESERVE:
BUSINESS MODEL
Biomaterial
transportation
company
transportation
company
Sales of equipment
(fridges) leveraging
InPres technology
(fridges) leveraging
InPres technology
Sell technology/
IP license
IP license
TECHNOLOGY BASE
High Pressure Gas
Gas Mixture
Device & Software
Preservation & Unpreservation
Method:
High Pressure Gas
Preservation & Unpreservation
Method:
Gas Mixture
Device & Software
TECHNOLOGY BASE
DEVICE & SOFTWARE
High pressure chamber
Powered by original protocol
Harnessing precise sensors
DEVICE & SOFTWARE
High pressure chamber
Powered by original protocol
Harnessing precise sensors
COMPETITIVE ADVANTAGES
Reliable
& safe:
& safe:
no moving parts, high autonomy,
simple operation
simple operation
x2
More storage time
= more organs, less risk
= more organs, less risk
<10
Less product & operations cost
PARTNERS
Almazov Federal Research Center
Saint Petersburg, Russian Federation
Novosibirsk, Russian Federation
National Medical Research Meshalkin Center
High class heart surgeons and anaesthesiologists
Ural Branch, Russian Federation
Russian Academy of Science Physiology Instituter
High end vivarium & lab equipment capable to test of any scientific hypothesis
R&D with skilled staff
Pre clinical trials
CURRENT STATUS
2010
First grant for gas preservation concept
First grant for gas preservation concept
Funding from IPF to develop schematics for gaseous preservation of viable cell grafts
2011
Prototype for tissue and cell experiments
Prototype for tissue and cell experiments
Equipment built for testing small tissue samples and cell suspensions
2012
Experimental preservation in gas
Experimental preservation in gas
Preservation of various cells in a gas mixture tested experimentally
InPres LLC founded
Company established with funding from a local innovation center
2013
Collaboration with Aalborg University
Collaboration with Aalborg University
Electron microscopy confirms feasibility of preserving stem cells and RBCs in a modified gas atmosphere
2014
Second grant and upgraded equipment
Second grant and upgraded equipment
InPres receives a second round of funding from IPF and develops next-generation preservation hardware
2015
RBCs and skin grafts preserved in gas
RBCs and skin grafts preserved in gas
Preservation of red blood cells and skin grafts demonstrated; results presented at international scientific meetings
2016
Thesis on gas preservation defended
Thesis on gas preservation defended
Alexander Ponomarev successfully defends his dissertation on gas-based preservation methods
2017
Two patents obtained
Two patents obtained
Official patents granted for core developments in gas-based preservation technology
2018
International publication released
International publication released
Summary of RBC and stem cell preservation experiments published in Cryo-Letters
2019
Rat heart preserved and transplanted
Rat heart preserved and transplanted
11-hour preservation followed by successful heterotopic transplantation at Shumakov National Research Center
2020
Pilot study on rats’ heart preservation
Pilot study on rats’ heart preservation
Followed by Langendorff evaluation at Almazov National Research Center
2022
First funding round from Kamaflow VC
First funding round from Kamaflow VC
Money obtained from VC Kamaflow
2023
Huge leap in scalability for large organs
Huge leap in scalability for large organs
New capacious and smart equipment developed; new patents pending
2024
Pilot study on rabbit lung preservation
Pilot study on rabbit lung preservation
Ex-vivo evaluation at First Pavlov Medical University, Saint Petersburg
Pilot study on pig heart preservation
8.5 hours of preservation at Meshalkin’s Center
We are looking for
Partnership in transplantological area to run further experiments/preclinical trials
